Uracil derivatives as HIV-1 capsid protein inhibitors: design, in silico, in vitro and cytotoxicity studies

A series of novel uracil derivatives such as bispyrimidine dione and tetrapyrimidine dione derivatives were designed based on the existing four-point pharmacophore model as effective HIV capsid protein inhibitors. The compounds were initially docked with an HIV capsid protein monomer to rationalize...

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Detalles Bibliográficos
Autores principales: Ramesh, Deepthi, Mohanty, Amaresh Kumar, De, Anirban, Vijayakumar, Balaji Gowrivel, Sethumadhavan, Aiswarya, Muthuvel, Suresh Kumar, Mani, Maheswaran, Kannan, Tharanikkarasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190787/
https://www.ncbi.nlm.nih.gov/pubmed/35765450
http://dx.doi.org/10.1039/d2ra02450k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190787/
https://www.ncbi.nlm.nih.gov/pubmed/35765450
http://dx.doi.org/10.1039/d2ra02450k

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