Leveraging intrinsic flexibility to engineer enhanced enzyme catalytic activity

Dynamic motions of enzymes occurring on a broad range of timescales play a pivotal role in all steps of the reaction pathway, including substrate binding, catalysis, and product release. However, it is unknown whether structural information related to conformational flexibility can be exploited for...

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Detalles Bibliográficos
Autores principales: Karamitros, Christos S., Murray, Kyle, Winemiller, Brent, Lamb, Candice, Stone, Everett M., D'Arcy, Sheena, Johnson, Kenneth A., Georgiou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191678/
https://www.ncbi.nlm.nih.gov/pubmed/35658075
http://dx.doi.org/10.1073/pnas.2118979119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191678/
https://www.ncbi.nlm.nih.gov/pubmed/35658075
http://dx.doi.org/10.1073/pnas.2118979119

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