E- and Z-Trisubstituted macrocyclic alkenes for natural product synthesis and skeletal editing

Many therapeutic agents are macrocyclic trisubstituted alkenes, and yet, preparation of these structures is typically inefficient and nonselective. A possible solution would entail catalytic macrocyclic ring-closing metathesis, but these transformations require high catalyst loading, conformationall...

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Detalles Bibliográficos
Autores principales: Mu, Yucheng, Hartrampf, Felix W. W., Yu, Elsie C., Lounsbury, Katherine E., Schrock, Richard R., Romiti, Filippo, Hoveyda, Amir H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191848/
https://www.ncbi.nlm.nih.gov/pubmed/35577918
http://dx.doi.org/10.1038/s41557-022-00935-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191848/
https://www.ncbi.nlm.nih.gov/pubmed/35577918
http://dx.doi.org/10.1038/s41557-022-00935-y

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