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E- and Z-Trisubstituted macrocyclic alkenes for natural product synthesis and skeletal editing
Many therapeutic agents are macrocyclic trisubstituted alkenes, and yet, preparation of these structures is typically inefficient and nonselective. A possible solution would entail catalytic macrocyclic ring-closing metathesis, but these transformations require high catalyst loading, conformationall...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191848/ https://www.ncbi.nlm.nih.gov/pubmed/35577918 http://dx.doi.org/10.1038/s41557-022-00935-y |