Systematic lncRNA mapping to genome-wide co-essential modules uncovers cancer dependency on uncharacterized lncRNAs

Quantification of gene dependency across hundreds of cell lines using genome-scale CRISPR screens has revealed co-essential pathways/modules and critical functions of uncharacterized genes. In contrast to protein-coding genes, robust CRISPR-based loss-of-function screens are lacking for long noncodi...

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Detalles Bibliográficos
Autores principales: Mitra, Ramkrishna, Adams, Clare M, Eischen, Christine M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191893/
https://www.ncbi.nlm.nih.gov/pubmed/35695878
http://dx.doi.org/10.7554/eLife.77357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9191893/
https://www.ncbi.nlm.nih.gov/pubmed/35695878
http://dx.doi.org/10.7554/eLife.77357

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