Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis

BRCA2-deficient cells precipitate telomere shortening upon collapse of stalled replication forks. Here, we report that the dynamic interaction between BRCA2 and telomeric G-quadruplex (G4), the non-canonical four-stranded secondary structure, underlies telomere replication homeostasis. We find that...

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Detalles Bibliográficos
Autores principales: Lee, Junyeop, Sung, Keewon, Joo, So Young, Jeong, Jun-Hyeon, Kim, Seong Keun, Lee, Hyunsook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192595/
https://www.ncbi.nlm.nih.gov/pubmed/35697743
http://dx.doi.org/10.1038/s41467-022-31156-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192595/
https://www.ncbi.nlm.nih.gov/pubmed/35697743
http://dx.doi.org/10.1038/s41467-022-31156-z

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