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Dynamic interaction of BRCA2 with telomeric G-quadruplexes underlies telomere replication homeostasis
BRCA2-deficient cells precipitate telomere shortening upon collapse of stalled replication forks. Here, we report that the dynamic interaction between BRCA2 and telomeric G-quadruplex (G4), the non-canonical four-stranded secondary structure, underlies telomere replication homeostasis. We find that...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192595/ https://www.ncbi.nlm.nih.gov/pubmed/35697743 http://dx.doi.org/10.1038/s41467-022-31156-z |