PI3K/Akt pathway mediates the positive inotropic effects of insulin in Langendorff-perfused rat hearts

Insulin exerts positive inotropic effects on cardiac muscle; however, the relationship between cardiac contractility and phosphoinositol-3-kinase/Akt (PI3K/Akt) activation remains unclear. We hypothesized that the positive inotropic effects of insulin are dose-dependent and mediated via the PI3K/Akt...

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Detalles Bibliográficos
Autores principales: Nakadate, Yosuke, Kawakami, Akiko, Sato, Hiroaki, Sato, Tamaki, Oguchi, Takeshi, Omiya, Keisuke, Matsuoka, Toru, Schricker, Thomas, Matsukawa, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192604/
https://www.ncbi.nlm.nih.gov/pubmed/35697740
http://dx.doi.org/10.1038/s41598-022-14092-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192604/
https://www.ncbi.nlm.nih.gov/pubmed/35697740
http://dx.doi.org/10.1038/s41598-022-14092-2

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