Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies
PURPOSE: To describe a case series of peripheral ulcerative keratitis (PUK) as a paraneoplastic condition in three patients with known underlying systemic solid tumor malignancies. OBSERVATIONS: Three patients with different systemic malignancies (1 recurrent breast cancer, 1 metastatic thyroid canc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193368/ https://www.ncbi.nlm.nih.gov/pubmed/35712100 http://dx.doi.org/10.3389/fmed.2022.907285 |
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author | Foo, Valencia Hui Xian Mehta, Jodhbir Chan, Anita Sook Yee Ong, Hon Shing |
author_facet | Foo, Valencia Hui Xian Mehta, Jodhbir Chan, Anita Sook Yee Ong, Hon Shing |
author_sort | Foo, Valencia Hui Xian |
collection | PubMed |
description | PURPOSE: To describe a case series of peripheral ulcerative keratitis (PUK) as a paraneoplastic condition in three patients with known underlying systemic solid tumor malignancies. OBSERVATIONS: Three patients with different systemic malignancies (1 recurrent breast cancer, 1 metastatic thyroid cancer, and 1 metastatic gastric adenocarcinoma) were identified to have PUK with significant corneal stromal melt. Autoimmune and infective work up for other etiologies were all negative. They all responded well to topical steroids and intravenous methylprednisolone. One patient had recurrences of her PUK and required repeated amniotic grafts and tectonic keratoplasties before her corneal condition stabilized. CONCLUSIONS AND IMPORTANCE: PUK can be a rare manifestation of systemic solid tumor malignancies. Although PUK may not be an indicator of progression of the underlying malignancy, it can be sight-threatening. This case series highlights the necessity for clinicians to refer patients with systemic malignancies presenting with inflamed eyes for an early ophthalmological review. This facilitates the detection of this blinding disease, allowing for early therapeutic interventions and potentially better visual outcomes for these patients. |
format | Online Article Text |
id | pubmed-9193368 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91933682022-06-15 Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies Foo, Valencia Hui Xian Mehta, Jodhbir Chan, Anita Sook Yee Ong, Hon Shing Front Med (Lausanne) Medicine PURPOSE: To describe a case series of peripheral ulcerative keratitis (PUK) as a paraneoplastic condition in three patients with known underlying systemic solid tumor malignancies. OBSERVATIONS: Three patients with different systemic malignancies (1 recurrent breast cancer, 1 metastatic thyroid cancer, and 1 metastatic gastric adenocarcinoma) were identified to have PUK with significant corneal stromal melt. Autoimmune and infective work up for other etiologies were all negative. They all responded well to topical steroids and intravenous methylprednisolone. One patient had recurrences of her PUK and required repeated amniotic grafts and tectonic keratoplasties before her corneal condition stabilized. CONCLUSIONS AND IMPORTANCE: PUK can be a rare manifestation of systemic solid tumor malignancies. Although PUK may not be an indicator of progression of the underlying malignancy, it can be sight-threatening. This case series highlights the necessity for clinicians to refer patients with systemic malignancies presenting with inflamed eyes for an early ophthalmological review. This facilitates the detection of this blinding disease, allowing for early therapeutic interventions and potentially better visual outcomes for these patients. Frontiers Media S.A. 2022-05-31 /pmc/articles/PMC9193368/ /pubmed/35712100 http://dx.doi.org/10.3389/fmed.2022.907285 Text en Copyright © 2022 Foo, Mehta, Chan and Ong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Foo, Valencia Hui Xian Mehta, Jodhbir Chan, Anita Sook Yee Ong, Hon Shing Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies |
title | Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies |
title_full | Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies |
title_fullStr | Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies |
title_full_unstemmed | Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies |
title_short | Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies |
title_sort | case report: peripheral ulcerative keratitis in systemic solid tumour malignancies |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193368/ https://www.ncbi.nlm.nih.gov/pubmed/35712100 http://dx.doi.org/10.3389/fmed.2022.907285 |
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