Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies

PURPOSE: To describe a case series of peripheral ulcerative keratitis (PUK) as a paraneoplastic condition in three patients with known underlying systemic solid tumor malignancies. OBSERVATIONS: Three patients with different systemic malignancies (1 recurrent breast cancer, 1 metastatic thyroid canc...

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Autores principales: Foo, Valencia Hui Xian, Mehta, Jodhbir, Chan, Anita Sook Yee, Ong, Hon Shing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193368/
https://www.ncbi.nlm.nih.gov/pubmed/35712100
http://dx.doi.org/10.3389/fmed.2022.907285
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author Foo, Valencia Hui Xian
Mehta, Jodhbir
Chan, Anita Sook Yee
Ong, Hon Shing
author_facet Foo, Valencia Hui Xian
Mehta, Jodhbir
Chan, Anita Sook Yee
Ong, Hon Shing
author_sort Foo, Valencia Hui Xian
collection PubMed
description PURPOSE: To describe a case series of peripheral ulcerative keratitis (PUK) as a paraneoplastic condition in three patients with known underlying systemic solid tumor malignancies. OBSERVATIONS: Three patients with different systemic malignancies (1 recurrent breast cancer, 1 metastatic thyroid cancer, and 1 metastatic gastric adenocarcinoma) were identified to have PUK with significant corneal stromal melt. Autoimmune and infective work up for other etiologies were all negative. They all responded well to topical steroids and intravenous methylprednisolone. One patient had recurrences of her PUK and required repeated amniotic grafts and tectonic keratoplasties before her corneal condition stabilized. CONCLUSIONS AND IMPORTANCE: PUK can be a rare manifestation of systemic solid tumor malignancies. Although PUK may not be an indicator of progression of the underlying malignancy, it can be sight-threatening. This case series highlights the necessity for clinicians to refer patients with systemic malignancies presenting with inflamed eyes for an early ophthalmological review. This facilitates the detection of this blinding disease, allowing for early therapeutic interventions and potentially better visual outcomes for these patients.
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spelling pubmed-91933682022-06-15 Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies Foo, Valencia Hui Xian Mehta, Jodhbir Chan, Anita Sook Yee Ong, Hon Shing Front Med (Lausanne) Medicine PURPOSE: To describe a case series of peripheral ulcerative keratitis (PUK) as a paraneoplastic condition in three patients with known underlying systemic solid tumor malignancies. OBSERVATIONS: Three patients with different systemic malignancies (1 recurrent breast cancer, 1 metastatic thyroid cancer, and 1 metastatic gastric adenocarcinoma) were identified to have PUK with significant corneal stromal melt. Autoimmune and infective work up for other etiologies were all negative. They all responded well to topical steroids and intravenous methylprednisolone. One patient had recurrences of her PUK and required repeated amniotic grafts and tectonic keratoplasties before her corneal condition stabilized. CONCLUSIONS AND IMPORTANCE: PUK can be a rare manifestation of systemic solid tumor malignancies. Although PUK may not be an indicator of progression of the underlying malignancy, it can be sight-threatening. This case series highlights the necessity for clinicians to refer patients with systemic malignancies presenting with inflamed eyes for an early ophthalmological review. This facilitates the detection of this blinding disease, allowing for early therapeutic interventions and potentially better visual outcomes for these patients. Frontiers Media S.A. 2022-05-31 /pmc/articles/PMC9193368/ /pubmed/35712100 http://dx.doi.org/10.3389/fmed.2022.907285 Text en Copyright © 2022 Foo, Mehta, Chan and Ong. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Foo, Valencia Hui Xian
Mehta, Jodhbir
Chan, Anita Sook Yee
Ong, Hon Shing
Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies
title Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies
title_full Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies
title_fullStr Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies
title_full_unstemmed Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies
title_short Case Report: Peripheral Ulcerative Keratitis in Systemic Solid Tumour Malignancies
title_sort case report: peripheral ulcerative keratitis in systemic solid tumour malignancies
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193368/
https://www.ncbi.nlm.nih.gov/pubmed/35712100
http://dx.doi.org/10.3389/fmed.2022.907285
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