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Differential Effects of mTORC1 and mTORC2 Inhibition on High-Resolution Mass Spectrometry (HRMS) Metabolomics and the Internal Exposome in Pancreatic Beta Cell Lines
OBJECTIVES: The mechanistic Target of Rapamycin Complexes (mTORC1/mTORC2) are critical nodes for metabolism. We applied an HRMS-based untargeted metabolomics approach to determine the role of mTORC1/mTORC2 on the internal exposome in pancreatic cell line (β-TC6). mTORC1 is a nutrient-sensing network...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193525/ http://dx.doi.org/10.1093/cdn/nzac078.020 |