Inflammatory-Dependent Bidirectional Effect of Bile Acids on NLRP3 Inflammasome and Its Role in Ameliorating CPT-11-Induced Colitis

Irinotecan (CPT-11) in combination with 5-fluorouracil and leucovorin is a first-line chemotherapy regimen for the treatment of colorectal cancer; however, its clinical application is limited by the dose-limiting gastrointestinal toxicity of colitis. In our previous studies, several bile acids (BAs)...

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Detalles Bibliográficos
Autores principales: Liao, Chuyao, Wang, Di, Qin, Siyuan, Zhang, Ying, Chen, Jie, Xu, Ruijie, Xu, Fengguo, Zhang, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193974/
https://www.ncbi.nlm.nih.gov/pubmed/35712724
http://dx.doi.org/10.3389/fphar.2022.677738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9193974/
https://www.ncbi.nlm.nih.gov/pubmed/35712724
http://dx.doi.org/10.3389/fphar.2022.677738

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