Lymphocyte-Specific Protein-1 Suppresses Xenobiotic-Induced Constitutive Androstane Receptor and Subsequent Yes-Associated Protein–Activated Hepatocyte Proliferation

Activation of constitutive androstane receptor (CAR) transcription factor by xenobiotics promotes hepatocellular proliferation, promotes hypertrophy without liver injury, and induces drug metabolism genes. Previous work demonstrated that lymphocyte-specific protein-1 (LSP1), an F-actin binding prote...

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Detalles Bibliográficos
Autores principales: Koral, Kelly, Bhushan, Bharat, Orr, Anne, Stoops, John, Bowen, William C., Copeland, Matthew A., Locker, Joseph, Mars, Wendy M., Michalopoulos, George K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Investigative Pathology 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194659/
https://www.ncbi.nlm.nih.gov/pubmed/35390317
http://dx.doi.org/10.1016/j.ajpath.2022.03.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194659/
https://www.ncbi.nlm.nih.gov/pubmed/35390317
http://dx.doi.org/10.1016/j.ajpath.2022.03.010

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