Structural basis for feedforward control in the PINK1/Parkin pathway

PINK1 and parkin constitute a mitochondrial quality control system mutated in Parkinson’s disease. PINK1, a kinase, phosphorylates ubiquitin to recruit parkin, an E3 ubiquitin ligase, to mitochondria. PINK1 controls both parkin localization and activity through phosphorylation of both ubiquitin and...

Descripción completa

Detalles Bibliográficos
Autores principales: Sauvé, Véronique, Sung, George, MacDougall, Emma J, Kozlov, Guennadi, Saran, Anshu, Fakih, Rayan, Fon, Edward A, Gehring, Kalle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194792/
https://www.ncbi.nlm.nih.gov/pubmed/35491809
http://dx.doi.org/10.15252/embj.2021109460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194792/
https://www.ncbi.nlm.nih.gov/pubmed/35491809
http://dx.doi.org/10.15252/embj.2021109460

Ejemplares similares