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Structural basis for feedforward control in the PINK1/Parkin pathway

PINK1 and parkin constitute a mitochondrial quality control system mutated in Parkinson’s disease. PINK1, a kinase, phosphorylates ubiquitin to recruit parkin, an E3 ubiquitin ligase, to mitochondria. PINK1 controls both parkin localization and activity through phosphorylation of both ubiquitin and...

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Detalles Bibliográficos
Autores principales:	Sauvé, Véronique, Sung, George, MacDougall, Emma J, Kozlov, Guennadi, Saran, Anshu, Fakih, Rayan, Fon, Edward A, Gehring, Kalle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194792/ https://www.ncbi.nlm.nih.gov/pubmed/35491809 http://dx.doi.org/10.15252/embj.2021109460

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