Gating and anion selectivity are reciprocally regulated in TMEM16A (ANO1)

Numerous essential physiological processes depend on the TMEM16A-mediated Ca(2+)-activated chloride fluxes. Extensive structure–function studies have helped to elucidate the Ca(2+) gating mechanism of TMEM16A, revealing a Ca(2+)-sensing element close to the anion pore that alters conduction. However...

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Detalles Bibliográficos
Autores principales: De Jesús-Pérez, José J., López-Romero, Ana E., Posadas, Odalys, Segura-Covarrubias, Guadalupe, Aréchiga-Figueroa, Iván, Gutiérrez-Medina, Braulio, Pérez-Cornejo, Patricia, Arreola, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194859/
https://www.ncbi.nlm.nih.gov/pubmed/35687042
http://dx.doi.org/10.1085/jgp.202113027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194859/
https://www.ncbi.nlm.nih.gov/pubmed/35687042
http://dx.doi.org/10.1085/jgp.202113027

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