Prolonged deprivation of arginine or leucine induces PI3K/Akt-dependent reactivation of mTORC1

The mechanistic target of rapamycin complex 1 (mTORC1) is a serine/threonine kinase complex that promotes anabolic processes including protein, lipid, and nucleotide synthesis, while suppressing catabolic processes such as macroautophagy. mTORC1 activity is regulated by growth factors and amino acid...

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Detalles Bibliográficos
Autores principales: Buel, Gwen R., Dang, Huy Q., Asara, John M., Blenis, John, Mutvei, Anders P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194872/
https://www.ncbi.nlm.nih.gov/pubmed/35577075
http://dx.doi.org/10.1016/j.jbc.2022.102030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194872/
https://www.ncbi.nlm.nih.gov/pubmed/35577075
http://dx.doi.org/10.1016/j.jbc.2022.102030

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