Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors

[Image: see text] Perforin is a key effector of lymphocyte-mediated cell death pathways and contributes to transplant rejection of immunologically mismatched grafts. We have developed a novel series of benzenesulfonamide (BZS) inhibitors of perforin that can mitigate graft rejection during allogenei...

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Detalles Bibliográficos
Autores principales: Gartlan, Kate H., Jaiswal, Jagdish K., Bull, Matthew R., Akhlaghi, Hedieh, Sutton, Vivien R., Alexander, Kylie A., Chang, Karshing, Hill, Geoffrey R., Miller, Christian K., O’Connor, Patrick D., Jose, Jiney, Trapani, Joseph A., Charman, Susan A., Spicer, Julie A., Jamieson, Stephen M. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194936/
https://www.ncbi.nlm.nih.gov/pubmed/35711815
http://dx.doi.org/10.1021/acsptsci.2c00009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194936/
https://www.ncbi.nlm.nih.gov/pubmed/35711815
http://dx.doi.org/10.1021/acsptsci.2c00009

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