Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice

Dysfunction of striatal dopaminergic circuits has been implicated in motor impairment and Parkinson’s disease (PD)-related circadian perturbations that may represent an early prodromal marker of PD. Cyclin-dependent kinase 5 (CDK5) negatively regulates dopamine signaling in the striatum, suggesting...

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Detalles Bibliográficos
Autores principales: Zhou, Hu, Zhang, Jingxin, Shi, Huaxiang, Li, Pengfei, Sui, Xin, Wang, Yongan, Wang, Liyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195255/
https://www.ncbi.nlm.nih.gov/pubmed/35701839
http://dx.doi.org/10.1186/s13041-022-00939-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195255/
https://www.ncbi.nlm.nih.gov/pubmed/35701839
http://dx.doi.org/10.1186/s13041-022-00939-2

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