CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes

Regulation of endosomal Toll-like receptor (TLR) responses by the chemokine CXCL4 is implicated in inflammatory and fibrotic diseases, with CXCL4 proposed to potentiate TLR responses by binding to nucleic acid TLR ligands and facilitating their endosomal delivery. Here we report that in human monocy...

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Detalles Bibliográficos
Autores principales: Yang, Chao, Bachu, Mahesh, Du, Yong, Brauner, Caroline, Yuan, Ruoxi, Ah Kioon, Marie Dominique, Chesi, Giancarlo, Barrat, Franck J., Ivashkiv, Lionel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195402/
https://www.ncbi.nlm.nih.gov/pubmed/35701499
http://dx.doi.org/10.1038/s41467-022-31132-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195402/
https://www.ncbi.nlm.nih.gov/pubmed/35701499
http://dx.doi.org/10.1038/s41467-022-31132-7

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