Cargando…

CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes

Regulation of endosomal Toll-like receptor (TLR) responses by the chemokine CXCL4 is implicated in inflammatory and fibrotic diseases, with CXCL4 proposed to potentiate TLR responses by binding to nucleic acid TLR ligands and facilitating their endosomal delivery. Here we report that in human monocy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Chao, Bachu, Mahesh, Du, Yong, Brauner, Caroline, Yuan, Ruoxi, Ah Kioon, Marie Dominique, Chesi, Giancarlo, Barrat, Franck J., Ivashkiv, Lionel B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195402/ https://www.ncbi.nlm.nih.gov/pubmed/35701499 http://dx.doi.org/10.1038/s41467-022-31132-7

Ejemplares similares

Chemokines form nanoparticles with DNA and can superinduce TLR-driven immune inflammation
por: Du, Yong, et al.
Publicado: (2022)

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation
por: Kang, Kyuho, et al.
Publicado: (2019)

Rebamipide suppresses TLR-TBK1 signaling pathway resulting in regulating IRF3/7 and IFN-α/β reduction
por: Ogasawara, Naotaka, et al.
Publicado: (2011)

TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation
por: Hu, Yi Wei, et al.
Publicado: (2018)

Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway
por: Black, Katharine E, et al.
Publicado: (2013)

Stearic Acid and TNF-α Co-Operatively Potentiate MIP-1α Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway
por: Kochumon, Shihab, et al.
Publicado: (2020)

TLR8: No gain, no pain
por: Barrat, Franck J.
Publicado: (2018)

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β
por: Bakshi, Siddharth, et al.
Publicado: (2017)

The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis
por: Roberts, Zachary J., et al.
Publicado: (2007)

PGAM5-MAVS interaction regulates TBK1/ IRF3 dependent antiviral responses
por: Yu, Yu-qiang, et al.
Publicado: (2020)

TBK1 and IRF3 are potential therapeutic targets in Enterovirus A71-associated diseases
por: Ji, Wangquan, et al.
Publicado: (2023)

The STING/TBK1/IRF3/IFN type I pathway is defective in cystic fibrosis
por: Occhigrossi, Luca, et al.
Publicado: (2023)

TLR8 escapes X chromosome inactivation in human monocytes and CD4(+) T cells
por: Youness, Ali, et al.
Publicado: (2023)

A Novel Transcript Isoform of TBK1 Negatively Regulates Type I IFN Production by Promoting Proteasomal Degradation of TBK1 and Lysosomal Degradation of IRF3
por: Zhang, Jie, et al.
Publicado: (2020)

Thymoquinone Suppresses IRF-3-Mediated Expression of Type I Interferons via Suppression of TBK1
por: Aziz, Nur, et al.
Publicado: (2018)

Molecular characterization, expression of chicken TBK1 gene and its effect on IRF3 signaling pathway
por: Wang, Yan, et al.
Publicado: (2017)

UBQLN2 Promotes the Production of Type I Interferon via the TBK1-IRF3 Pathway
por: Chen, Tianhong, et al.
Publicado: (2020)

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7
por: Unterholzner, Leonie, et al.
Publicado: (2011)

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation
por: Guiducci, Cristiana, et al.
Publicado: (2008)

ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction
por: He, Xiang, et al.
Publicado: (2017)

IRF1 Maintains Optimal Constitutive Expression of Antiviral Genes and Regulates the Early Antiviral Response
por: Panda, Debasis, et al.
Publicado: (2019)

Regulation of Age-associated B cells by IRF5 in systemic autoimmunity
por: Manni, Michela, et al.
Publicado: (2018)

Porcine Epidemic Diarrhea Virus nsp15 Antagonizes Interferon Signaling by RNA Degradation of TBK1 and IRF3
por: Wu, Yang, et al.
Publicado: (2020)

Identification of Small GTPases That Phosphorylate IRF3 through TBK1 Activation Using an Active Mutant Library Screen
por: Yu, Jae-Hyun, et al.
Publicado: (2023)

Epigenomics of conventional type-I dendritic cells depicted preferential control of TLR9 versus TLR3 response by NCoR1 through differential IRF3 activation
por: Mishra, Gyan Prakash, et al.
Publicado: (2022)

Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4
por: Collins, Paul J., et al.
Publicado: (2017)

cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection
por: Li, Qiang, et al.
Publicado: (2019)

Histone acetyl transferase TIP60 inhibits the replication of influenza a virus by activation the TBK1-IRF3 pathway
por: Ma, Guoyao, et al.
Publicado: (2018)

Palmitic Acid Promotes Virus Replication in Fish Cell by Modulating Autophagy Flux and TBK1-IRF3/7 Pathway
por: Yu, Yepin, et al.
Publicado: (2020)

Viral infection of cells within the tumor microenvironment mediates antitumor immunotherapy via selective TBK1-IRF3 signaling
por: Brown, Michael C., et al.
Publicado: (2021)

Broadly Antiviral Activities of TAP1 through Activating the TBK1-IRF3-Mediated Type I Interferon Production
por: Zhao, Jin, et al.
Publicado: (2021)

The cGAS/STING–TBK1–IRF Regulatory Axis Orchestrates a Primitive Interferon-Like Antiviral Mechanism in Oyster
por: Qiao, Xue, et al.
Publicado: (2021)

CXCL14 Preferentially Synergizes With Homeostatic Chemokine Receptor Systems
por: Kouzeli, Ariadni, et al.
Publicado: (2020)

Swine IRF3/IRF7 attenuates inflammatory responses through TLR4 signaling pathway
por: Chen, Pei-Ge, et al.
Publicado: (2017)

TLR Signaling Paralyzes Monocyte Chemotaxis through Synergized Effects of p38 MAPK and Global Rap-1 Activation
por: Yi, Ling, et al.
Publicado: (2012)

Molecular Mechanisms That Underlie the Dynamic Adaptation of Innate Monocyte Memory to Varying Stimulant Strength of TLR Ligands
por: Yuan, Ruoxi, et al.
Publicado: (2016)

Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis
por: Luo, Xiaogang, et al.
Publicado: (2023)

Type I IFNs and TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation
por: Park, Sung Ho, et al.
Publicado: (2017)

ATP128 Clinical Therapeutic Cancer Vaccine Activates NF-κB and IRF3 Pathways through TLR4 and TLR2 in Human Monocytes and Dendritic Cells
por: Pascolutti, Roberta, et al.
Publicado: (2022)

The synergized diagnostic value of VTQ with chemokine CXCL13 in lung tumors
por: Zhang, Xu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bmhf0uciqlel26sadhmkuqjv5h