Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

BACKGROUND: Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indispensable role, however, its mechanism of action (MoA) is not fully understood....

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Detalles Bibliográficos
Autores principales: Gao, Peng, Liu, Yan-Qing, Xiao, Wei, Xia, Fei, Chen, Jia-Yun, Gu, Li-Wei, Yang, Fan, Zheng, Liu-Hai, Zhang, Jun-Zhe, Zhang, Qian, Li, Zhi-Jie, Meng, Yu-Qing, Zhu, Yong-Ping, Tang, Huan, Shi, Qiao-Li, Guo, Qiu-Yan, Zhang, Ying, Xu, Cheng-Chao, Dai, Ling-Yun, Wang, Ji-Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195458/
https://www.ncbi.nlm.nih.gov/pubmed/35698214
http://dx.doi.org/10.1186/s40779-022-00390-3

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