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Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA
BACKGROUND: Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indispensable role, however, its mechanism of action (MoA) is not fully understood....
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195458/ https://www.ncbi.nlm.nih.gov/pubmed/35698214 http://dx.doi.org/10.1186/s40779-022-00390-3 |