Maturation of the SARS-CoV-2 virus is regulated by dimerization of its main protease

SARS-CoV-2 main protease (M(pro)) involved in COVID-19 is required for maturation of the virus and infection of host cells. The key question is how to block the activity of M(pro). By combining atomistic simulations with machine learning, we found that the enzyme regulates its own activity by a coll...

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Detalles Bibliográficos
Autores principales: Kaptan, Shreyas, Girych, Mykhailo, Enkavi, Giray, Kulig, Waldemar, Sharma, Vivek, Vuorio, Joni, Rog, Tomasz, Vattulainen, Ilpo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195460/
https://www.ncbi.nlm.nih.gov/pubmed/35720615
http://dx.doi.org/10.1016/j.csbj.2022.06.023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195460/
https://www.ncbi.nlm.nih.gov/pubmed/35720615
http://dx.doi.org/10.1016/j.csbj.2022.06.023

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