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Tuning the Properties of Protein-Based Polymers Using High-Performance Orthogonal Translation Systems for the Incorporation of Aromatic Non-Canonical Amino Acids

The incorporation of non-canonical amino acids (ncAAs) using engineered aminoacyl-tRNA synthetases (aaRSs) has emerged as a powerful methodology to expand the chemical repertoire of proteins. However, the low efficiencies of typical aaRS variants limit the incorporation of ncAAs to only one or a few...

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Detalles Bibliográficos
Autores principales: Gueta, Osher, Sheinenzon, Ortal, Azulay, Rotem, Shalit, Hadas, Strugach, Daniela S., Hadar, Dagan, Gelkop, Sigal, Milo, Anat, Amiram, Miriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9195583/
https://www.ncbi.nlm.nih.gov/pubmed/35711629
http://dx.doi.org/10.3389/fbioe.2022.913057