Intestinal antiviral signaling is controlled by autophagy gene Epg5 independent of the microbiota

Mutations in the macroautophagy/autophagy gene EPG5 are responsible for Vici syndrome, a human genetic disease characterized by combined immunodeficiency. Previously, we found that epg5(−/-) mice exhibit hyperinflammation in the lungs mediated by IL1B/IL-1β and TNF/TNFα, resulting in resistance to i...

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Detalles Bibliográficos
Autores principales: Lee, Sanghyun, Kalugotla, Gowri, Ingle, Harshad, Rodgers, Rachel, Wu, Chunyan, Wang, Yating, Li, Yuhao, Yang, Xia, Zhang, Jin, Borella, Nicolette R., Deng, Hongju, Droit, Lindsay, Hill, Ryan, Peterson, Stefan T., Desai, Chandni, Lawrence, Dylan, Lu, Qun, Baldridge, Megan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196718/
https://www.ncbi.nlm.nih.gov/pubmed/34520306
http://dx.doi.org/10.1080/15548627.2021.1968607

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9196718/
https://www.ncbi.nlm.nih.gov/pubmed/34520306
http://dx.doi.org/10.1080/15548627.2021.1968607

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