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Pulmonary drug delivery and retention: A computational study to identify plausible parameters based on a coupled airway-mucus flow model

Pulmonary drug delivery systems rely on inhalation of drug-laden aerosols produced from aerosol generators such as inhalers, nebulizers etc. On deposition, the drug molecules diffuse in the mucus layer and are also subjected to mucociliary advection which transports the drugs away from the initial d...

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Detalles Bibliográficos
Autores principales: Chakravarty, Aranyak, Panchagnula, Mahesh V., Mohan, Alladi, Patankar, Neelesh A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197018/
https://www.ncbi.nlm.nih.gov/pubmed/35653381
http://dx.doi.org/10.1371/journal.pcbi.1010143