Aberrant induction of p19(Arf)-mediated cellular senescence contributes to neurodevelopmental defects

Valproic acid (VPA) is a widely prescribed drug to treat epilepsy, bipolar disorder, and migraine. If taken during pregnancy, however, exposure to the developing embryo can cause birth defects, cognitive impairment, and autism spectrum disorder. How VPA causes these developmental defects remains unk...

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Detalles Bibliográficos
Autores principales: Rhinn, Muriel, Zapata-Bodalo, Irene, Klein, Annabelle, Plassat, Jean-Luc, Knauer-Meyer, Tania, Keyes, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197032/
https://www.ncbi.nlm.nih.gov/pubmed/35700169
http://dx.doi.org/10.1371/journal.pbio.3001664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197032/
https://www.ncbi.nlm.nih.gov/pubmed/35700169
http://dx.doi.org/10.1371/journal.pbio.3001664

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