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Aberrant induction of p19(Arf)-mediated cellular senescence contributes to neurodevelopmental defects
Valproic acid (VPA) is a widely prescribed drug to treat epilepsy, bipolar disorder, and migraine. If taken during pregnancy, however, exposure to the developing embryo can cause birth defects, cognitive impairment, and autism spectrum disorder. How VPA causes these developmental defects remains unk...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197032/ https://www.ncbi.nlm.nih.gov/pubmed/35700169 http://dx.doi.org/10.1371/journal.pbio.3001664 |