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Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction
Sympathetic denervation of the heart following ischemia/reperfusion induced myocardial infarction (MI) is sustained by chondroitin sulfate proteoglycans (CSPGs) in the cardiac scar. Denervation predicts risk of sudden cardiac death in humans. Blocking CSPG signaling restores sympathetic axon outgrow...
Autores principales: | Blake, Matthew R, Parrish, Diana C, Staffenson, Melanie A, Sueda, Shanice, Woodward, William R, Habecker, Beth A |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197393/ https://www.ncbi.nlm.nih.gov/pubmed/35604022 http://dx.doi.org/10.7554/eLife.78387 |
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