Distinctive mechanisms of epilepsy-causing mutants discovered by measuring S4 movement in KCNQ2 channels

Neuronal KCNQ channels mediate the M-current, a key regulator of membrane excitability in the central and peripheral nervous systems. Mutations in KCNQ2 channels cause severe neurodevelopmental disorders, including epileptic encephalopathies. However, the impact that different mutations have on chan...

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Detalles Bibliográficos
Autores principales: Edmond, Michaela A, Hinojo-Perez, Andy, Wu, Xiaoan, Perez Rodriguez, Marta E, Barro-Soria, Rene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197397/
https://www.ncbi.nlm.nih.gov/pubmed/35642783
http://dx.doi.org/10.7554/eLife.77030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197397/
https://www.ncbi.nlm.nih.gov/pubmed/35642783
http://dx.doi.org/10.7554/eLife.77030

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