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Reducing ER stress with chaperone therapy reverses sleep fragmentation and cognitive decline in aged mice

As the aging population grows, the need to understand age‐related changes in health is vital. Two prominent behavioral changes that occur with age are disrupted sleep and impaired cognition. Sleep disruptions lead to perturbations in proteostasis and endoplasmic reticulum (ER) stress in mice. Furthe...

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Detalles Bibliográficos
Autores principales: Hafycz, Jennifer M., Strus, Ewa, Naidoo, Nirinjini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197403/
https://www.ncbi.nlm.nih.gov/pubmed/35488730
http://dx.doi.org/10.1111/acel.13598