Defective mitophagy in aged macrophages promotes mitochondrial DNA cytosolic leakage to activate STING signaling during liver sterile inflammation

Macrophage‐stimulator of interferon genes (STING) signaling mediated sterile inflammation has been implicated in various age‐related diseases. However, whether and how macrophage mitochondrial DNA (mtDNA) regulates STING signaling in aged macrophages remains largely unknown. We found that hypoxia‐re...

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Detalles Bibliográficos
Autores principales: Zhong, Weizhe, Rao, Zhuqing, Xu, Jian, Sun, Yu, Hu, Haoran, Wang, Ping, Xia, Yongxiang, Pan, Xiongxiong, Tang, Weiwei, Chen, Ziyi, Zhou, Haoming, Wang, Xuehao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197407/
https://www.ncbi.nlm.nih.gov/pubmed/35599014
http://dx.doi.org/10.1111/acel.13622

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197407/
https://www.ncbi.nlm.nih.gov/pubmed/35599014
http://dx.doi.org/10.1111/acel.13622

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