Non‐enzymatic function of WRN RECQL helicase regulates removal of topoisomerase‐I‐DNA covalent complexes and triggers NF‐κB signaling in cancer

Mutation in Werner (WRN) RECQL helicase is associated with premature aging syndrome (Werner syndrome, WS) and predisposition to multiple cancers. In patients with solid cancers, deficiency of the WRN RECQL helicase is paradoxically associated with enhanced overall survival in response to treatment w...

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Detalles Bibliográficos
Autores principales: Gupta, Pooja, Majumdar, Ananda Guha, Patro, Birija Sankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197415/
https://www.ncbi.nlm.nih.gov/pubmed/35582959
http://dx.doi.org/10.1111/acel.13625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197415/
https://www.ncbi.nlm.nih.gov/pubmed/35582959
http://dx.doi.org/10.1111/acel.13625

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