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Graft-versus-host disease: establishing IL-33 as an important costimulatory molecule

Approximately half of patients with hematologic malignancy who are treated with allogeneic hematopoietic stem cell transplantation (alloHCT) experience graft-versus-host disease (GVHD), which has high mortality rates despite immunosuppressive therapy. IL-12 is known to drive donor T cells toward an...

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Detalles Bibliográficos
Autores principales: Ferrara, James, Prado-Acosta, Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197507/
https://www.ncbi.nlm.nih.gov/pubmed/35703182
http://dx.doi.org/10.1172/JCI160692