Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis

The crosstalk between the BM microenvironment (niche) and hematopoietic stem cells (HSCs) is critical for HSC regeneration. Here, we show that in mice, deletion of the Fanconi anemia (FA) genes Fanca and Fancc dampened HSC regeneration through direct effects on HSCs and indirect effects on BM niche...

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Detalles Bibliográficos
Autores principales: Lin, Qiqi, Wu, Limei, Chatla, Srinivas, Chowdhury, Fabliha A., Atale, Neha, Joseph, Jonathan, Du, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197516/
https://www.ncbi.nlm.nih.gov/pubmed/35703178
http://dx.doi.org/10.1172/JCI155914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197516/
https://www.ncbi.nlm.nih.gov/pubmed/35703178
http://dx.doi.org/10.1172/JCI155914

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