Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder whose most debilitating pathology is progressive and cumulative heterotopic ossification (HO) of skeletal muscles, ligaments, tendons, and fascia. FOP is caused by mutations in the type I BMP receptor gene ACVR1, which enable ACV...

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Detalles Bibliográficos
Autores principales: Aykul, Senem, Huang, Lily, Wang, Lili, Das, Nanditha M., Reisman, Sandra, Ray, Yonaton, Zhang, Qian, Rothman, Nyanza, Nannuru, Kalyan C., Kamat, Vishal, Brydges, Susannah, Troncone, Luca, Johnsen, Laura, Yu, Paul B., Fazio, Sergio, Lees-Shepard, John, Schutz, Kevin, Murphy, Andrew J., Economides, Aris N., Idone, Vincent, Hatsell, Sarah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197526/
https://www.ncbi.nlm.nih.gov/pubmed/35511419
http://dx.doi.org/10.1172/JCI153792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197526/
https://www.ncbi.nlm.nih.gov/pubmed/35511419
http://dx.doi.org/10.1172/JCI153792

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