An anti-ACVR1 antibody exacerbates heterotopic ossification by fibro-adipogenic progenitors in fibrodysplasia ossificans progressiva mice

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by progressive and catastrophic heterotopic ossification (HO) of skeletal muscle and associated soft tissues. FOP is caused by dominantly acting mutations in the gene encoding the bone morphogenetic protein (BMP) typ...

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Detalles Bibliográficos
Autores principales: Lees-Shepard, John B., Stoessel, Sean J., Chandler, Julian T., Bouchard, Keith, Bento, Patricia, Apuzzo, Lorraine N., Devarakonda, Parvathi M., Hunter, Jeffrey W., Goldhamer, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197527/
https://www.ncbi.nlm.nih.gov/pubmed/35503416
http://dx.doi.org/10.1172/JCI153795

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197527/
https://www.ncbi.nlm.nih.gov/pubmed/35503416
http://dx.doi.org/10.1172/JCI153795

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