Model‐informed drug development of voxelotor in sickle cell disease: Exposure‐response analysis to support dosing and confirm mechanism of action

Sickle cell disease (SCD) is characterized by the production of sickle hemoglobin (HbS), which when deoxygenated, polymerizes leading to red blood cell damage and hemolytic anemia, a defining feature of SCD. Voxelotor (Oxbryta) is a small molecule inhibitor of HbS polymerization that disrupts the po...

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Detalles Bibliográficos
Autores principales: Green, Michelle L., Savic, Radojka M., Tonda, Margaret, Jorga, Karin, Washington, Carla B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197532/
https://www.ncbi.nlm.nih.gov/pubmed/35447017
http://dx.doi.org/10.1002/psp4.12780

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197532/
https://www.ncbi.nlm.nih.gov/pubmed/35447017
http://dx.doi.org/10.1002/psp4.12780

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