Population PBPK modeling using parametric and nonparametric methods of the Simcyp Simulator, and Bayesian samplers

Physiologically‐based pharmacokinetic (PBPK) models usually include a large number of parameters whose values are obtained using in vitro to in vivo extrapolation. However, such extrapolations can be uncertain and may benefit from inclusion of evidence from clinical observations via parametric infer...

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Detalles Bibliográficos
Autores principales: Wedagedera, Janak R., Afuape, Anthonia, Chirumamilla, Siri Kalyan, Momiji, Hiroshi, Leary, Robert, Dunlavey, Mike, Matthews, Richard, Abduljalil, Khaled, Jamei, Masoud, Bois, Frederic Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197540/
https://www.ncbi.nlm.nih.gov/pubmed/35385609
http://dx.doi.org/10.1002/psp4.12787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197540/
https://www.ncbi.nlm.nih.gov/pubmed/35385609
http://dx.doi.org/10.1002/psp4.12787

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