Immune disease risk variants regulate gene expression dynamics during CD4(+) T cell activation

During activation, T cells undergo extensive gene expression changes that shape the properties of cells to exert their effector function. Understanding the regulation of this process could help explain how genetic variants predispose to immune diseases. Here, we mapped genetic effects on gene expres...

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Detalles Bibliográficos
Autores principales: Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Ambridge, Kirsty, Ke, Ziying, Matte, Julie C., Bossini-Castillo, Lara, Kaplanis, Joanna, Ramirez-Navarro, Lucia, Lorenc, Anna, Nakic, Nikolina, Esparza-Gordillo, Jorge, Rowan, Wendy, Wille, David, Tough, David F., Bronson, Paola G., Trynka, Gosia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197762/
https://www.ncbi.nlm.nih.gov/pubmed/35618845
http://dx.doi.org/10.1038/s41588-022-01066-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197762/
https://www.ncbi.nlm.nih.gov/pubmed/35618845
http://dx.doi.org/10.1038/s41588-022-01066-3

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