Cargando…

Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse

We report an incidental 358.5 kb deletion spanning the region encoding for alpha-synuclein (αsyn) and multimerin1 (Mmrn1) in the Rab27a/Rab27b double knockout (DKO) mouse line previously developed by Tolmachova and colleagues in 2007. Western blot and RT-PCR studies revealed lack of αsyn expression...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pattanayak, Rudradip, Underwood, Rachel, Crowley, Michael R., Crossman, David K., Morgan, Jennifer R., Yacoubian, Talene A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197848/ https://www.ncbi.nlm.nih.gov/pubmed/35701443 http://dx.doi.org/10.1038/s41598-022-13557-8

Ejemplares similares

14-3-3 phosphorylation inhibits 14-3-3θ’s ability to regulate LRRK2 kinase activity
por: Pattanayak, Rudradip, et al.
Publicado: (2023)

14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in vivo preformed fibril model
por: Underwood, Rachel, et al.
Publicado: (2021)

The EMILIN/Multimerin Family
por: Colombatti, Alfonso, et al.
Publicado: (2012)

Defects in Very Long Chain Fatty Acid Synthesis Enhance Alpha-Synuclein Toxicity in a Yeast Model of Parkinson's Disease
por: Lee, Yong Joo, et al.
Publicado: (2011)

Multimerin-1 and cancer: a review
por: Posner, Mareike G.
Publicado: (2022)

The Binding of CD93 to Multimerin-2 Promotes Choroidal Neovascularization
por: Tosi, Gian Marco, et al.
Publicado: (2020)

Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface
por: Khan, K A, et al.
Publicado: (2017)

Molecular and functional interactions of alpha-synuclein with Rab3a
por: Lv, Guohua, et al.
Publicado: (2022)

The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/β1 integrin complex in endothelial cell adhesion and migration
por: Barbera, Stefano, et al.
Publicado: (2019)

14-3-3theta Protects against Neurotoxicity in a Cellular Parkinson's Disease Model through Inhibition of the Apoptotic Factor Bax
por: Slone, Sunny R., et al.
Publicado: (2011)

VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets
por: Satoh, Kaneo, et al.
Publicado: (2013)

Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis
por: Andreuzzi, Eva, et al.
Publicado: (2018)

Expression patterns and the prognostic value of the EMILIN/Multimerin family members in low-grade glioma
por: Zhao, Yonghui, et al.
Publicado: (2020)

Deletion of alpha-synuclein decreases impulsivity in mice
por: Peña-Oliver, Y, et al.
Publicado: (2012)

An insight to the binding of ellagic acid with human serum albumin using spectroscopic and isothermal calorimetry studies
por: Pattanayak, Rudradip, et al.
Publicado: (2017)

Revisiting Rab7 Functions in Mammalian Autophagy: Rab7 Knockout Studies
por: Kuchitsu, Yoshihiko, et al.
Publicado: (2018)

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
por: Qiao, Liyan, et al.
Publicado: (2008)

Prognostic Significance of Rab27A and Rab27B Expression in Esophageal Squamous Cell Cancer
por: Yu, Fengqiang, et al.
Publicado: (2020)

p27(Kip1) regulates alpha-synuclein expression
por: Gallastegui, Edurne, et al.
Publicado: (2018)

Multimerin-2 orchestrates the cross-talk between endothelial cells and pericytes: A mechanism to maintain vascular stability
por: Fejza, Albina, et al.
Publicado: (2021)

Dysregulation of 14‐3‐3 proteins in neurodegenerative diseases with Lewy body or Alzheimer pathology
por: McFerrin, Michael B., et al.
Publicado: (2017)

Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease
por: Wang, Hung-Li, et al.
Publicado: (2019)

Prognostic role of Rab27A and Rab27B expression in patients with non‐small cell lung carcinoma
por: Koh, Hyun Min, et al.
Publicado: (2018)

Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth
por: Ku, Kyung-Eun, et al.
Publicado: (2020)

MULTIMERIN2 binds VEGF-A primarily via the carbohydrate chains exerting an angiostatic function and impairing tumor growth
por: Colladel, Roberta, et al.
Publicado: (2015)

The Functions of the A1A2A3 Domains in Von Willebrand Factor Include Multimerin 1 Binding
por: Parker, D’Andra N., et al.
Publicado: (2016)

Multimerin 1 supports platelet function in vivo and binds to specific GPAGPOGPX motifs in fibrillar collagens that enhance platelet adhesion
por: Leatherdale, Alexander, et al.
Publicado: (2020)

Angiogenin in Parkinson Disease Models: Role of Akt Phosphorylation and Evaluation of AAV-Mediated Angiogenin Expression in MPTP Treated Mice
por: Steidinger, Trent U., et al.
Publicado: (2013)

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain
por: Xu, Enquan, et al.
Publicado: (2022)

Functional implications of Rab27 GTPases in Cancer
por: Li, Zhihong, et al.
Publicado: (2018)

Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour
por: Breda, Carlo, et al.
Publicado: (2015)

Comprehensive knockout analysis of the Rab family GTPases in epithelial cells
por: Homma, Yuta, et al.
Publicado: (2019)

Rab27a Regulates the Peripheral Distribution of Melanosomes in Melanocytes
por: Hume, Alistair N., et al.
Publicado: (2001)

Rab27a Is Required for Human Cytomegalovirus Assembly
por: Fraile-Ramos, Alberto, et al.
Publicado: (2010)

Rab27 in tick extracellular vesicle biogenesis and infection
por: Rainer Butler, L., et al.
Publicado: (2023)

Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation
por: Thomas, Bobby, et al.
Publicado: (2011)

Rab3GEP Is the Non-redundant Guanine Nucleotide Exchange Factor for Rab27a in Melanocytes
por: Figueiredo, Ana C., et al.
Publicado: (2008)

Correction: Resistance to MPTP-Neurotoxicity in α-Synuclein Knockout Mice Is Complemented by Human α-Synuclein and Associated with Increased β-Synuclein and Akt Activation
por: Thomas, Bobby, et al.
Publicado: (2012)

Rab27a Is Required for Regulated Secretion in Cytotoxic T Lymphocytes
por: Stinchcombe, Jane C., et al.
Publicado: (2001)

Rab27a builds a platform for HIV-1
por: Short, Ben
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_lck2mg94dheq84fjmoeshihe5q