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Cas9-induced large deletions and small indels are controlled in a convergent fashion

Repair of Cas9-induced double-stranded breaks results primarily in formation of small insertions and deletions (indels), but can also cause potentially harmful large deletions. While mechanisms leading to the creation of small indels are relatively well understood, very little is known about the ori...

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Detalles Bibliográficos
Autores principales: Kosicki, Michael, Allen, Felicity, Steward, Frances, Tomberg, Kärt, Pan, Yangyang, Bradley, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197861/
https://www.ncbi.nlm.nih.gov/pubmed/35701408
http://dx.doi.org/10.1038/s41467-022-30480-8