PAMAM versus PEI complexation for siRNA delivery: interaction with model lipid membranes and cellular uptake

PURPOSE: Cationic polymers have many advantages as vectors for mediated cellular entry and delivery of siRNA. However, toxicity related to their cationic charge has compromised clinical use. It is hypothesized that the siRNA-vector complex composition and properties can be controlled to optimize the...

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Detalles Bibliográficos
Autores principales: Chang, Patrick K. C., Prestidge, Clive A., Bremmell, Kristen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197904/
https://www.ncbi.nlm.nih.gov/pubmed/35318566
http://dx.doi.org/10.1007/s11095-022-03229-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197904/
https://www.ncbi.nlm.nih.gov/pubmed/35318566
http://dx.doi.org/10.1007/s11095-022-03229-7

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