Calcium Enabled Remote Loading of a Weak Acid Into pH-sensitive Liposomes and Augmented Cytosolic Delivery to Cancer Cells via the Proton Sponge Effect

While delivery of chemotherapeutics to cancer cells by nanomedicines can improve therapeutic outcomes, many fail due to the low drug loading (DL), poor cellular uptake and endosomal entrapment. This study investigated the potential to overcome these limitations using pH-sensitive liposomes (PSL) emp...

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Detalles Bibliográficos
Autores principales: Yang, Mimi M., Yarragudi, Sasi Bhushan, Jamieson, Stephen M. F., Tang, Mingtan, Wilson, William R., Wu, Zimei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197910/
https://www.ncbi.nlm.nih.gov/pubmed/35229237
http://dx.doi.org/10.1007/s11095-022-03206-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197910/
https://www.ncbi.nlm.nih.gov/pubmed/35229237
http://dx.doi.org/10.1007/s11095-022-03206-0

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