Disease modeling by efficient genome editing using a near PAM-less base editor in vivo

Base Editors are emerging as an innovative technology to introduce point mutations in complex genomes. So far, the requirement of an NGG Protospacer Adjacent Motif (PAM) at a suitable position often limits the base editing possibility to model human pathological mutations in animals. Here we show th...

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Detalles Bibliográficos
Autores principales: Rosello, Marion, Serafini, Malo, Mignani, Luca, Finazzi, Dario, Giovannangeli, Carine, Mione, Marina C., Concordet, Jean-Paul, Del Bene, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198099/
https://www.ncbi.nlm.nih.gov/pubmed/35701478
http://dx.doi.org/10.1038/s41467-022-31172-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198099/
https://www.ncbi.nlm.nih.gov/pubmed/35701478
http://dx.doi.org/10.1038/s41467-022-31172-z

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