Low-Dose Anti-HIV Drug Efavirenz Mitigates Retinal Vascular Lesions in a Mouse Model of Alzheimer’s Disease

A small dose of the anti-HIV drug efavirenz (EFV) was previously discovered to activate CYP46A1, a cholesterol-eliminating enzyme in the brain, and mitigate some of the manifestation of Alzheimer’s disease in 5XFAD mice. Herein, we investigated the retina of these animals, which were found to have g...

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Detalles Bibliográficos
Autores principales: El-Darzi, Nicole, Mast, Natalia, Buchner, David A., Saadane, Aicha, Dailey, Brian, Trichonas, Georgios, Pikuleva, Irina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198296/
https://www.ncbi.nlm.nih.gov/pubmed/35721135
http://dx.doi.org/10.3389/fphar.2022.902254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198296/
https://www.ncbi.nlm.nih.gov/pubmed/35721135
http://dx.doi.org/10.3389/fphar.2022.902254

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