Structural basis for the neurotropic AAV9 and the engineered AAVPHP.eB recognition with cellular receptors

Clade F adeno-associated virus (AAV) 9 has been utilized as therapeutic gene delivery vector, and it is capable of crossing blood brain barrier (BBB). Recently, an AAV9-based engineering serotype AAVPHP.eB with enhanced BBB crossing ability further expanded clade F AAVs’ usages in the murine central...

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Detalles Bibliográficos
Autores principales: Xu, Guangxue, Zhang, Ran, Li, Huapeng, Yin, Kaixin, Ma, Xinyi, Lou, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198364/
https://www.ncbi.nlm.nih.gov/pubmed/35755945
http://dx.doi.org/10.1016/j.omtm.2022.05.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198364/
https://www.ncbi.nlm.nih.gov/pubmed/35755945
http://dx.doi.org/10.1016/j.omtm.2022.05.009

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