O-fucosylation stabilizes the TSR3 motif in thrombospondin-1 by interacting with nearby amino acids and protecting a disulfide bond

Thrombospondin type-1 repeats (TSRs) are small protein motifs containing six conserved cysteines forming three disulfide bonds that can be modified with an O-linked fucose. Protein O-fucosyltransferase 2 (POFUT2) catalyzes the addition of O-fucose to TSRs containing the appropriate consensus sequenc...

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Detalles Bibliográficos
Autores principales: Berardinelli, Steven J., Eletsky, Alexander, Valero-González, Jessika, Ito, Atsuko, Manjunath, Rajashri, Hurtado-Guerrero, Ramon, Prestegard, James H., Woods, Robert J., Haltiwanger, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198472/
https://www.ncbi.nlm.nih.gov/pubmed/35597280
http://dx.doi.org/10.1016/j.jbc.2022.102047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198472/
https://www.ncbi.nlm.nih.gov/pubmed/35597280
http://dx.doi.org/10.1016/j.jbc.2022.102047

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