Mesenchymal Stromal Cell-Derived Extracellular Vesicles Modulate Hematopoietic Stem and Progenitor Cell Viability and the Expression of Cell Cycle Regulators in an Age-dependent Manner

Aging of the hematopoietic system is characterized by an expansion of hematopoietic stem and progenitor cells (HSPCs) with reduced capacity for engraftment, self-renewal, and lymphoid differentiation, resulting in myeloid-biased hematopoiesis. This process is mediated by both HSPC intrinsic and extr...

Descripción completa

Detalles Bibliográficos
Autores principales: Fichtel, Pascal, von Bonin, Malte, Kuhnert, Robert, Möbus, Kristin, Bornhäuser, Martin, Wobus, Manja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198480/
https://www.ncbi.nlm.nih.gov/pubmed/35721867
http://dx.doi.org/10.3389/fbioe.2022.892661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198480/
https://www.ncbi.nlm.nih.gov/pubmed/35721867
http://dx.doi.org/10.3389/fbioe.2022.892661

Ejemplares similares