Chloroquine Attenuates Asthma Development by Restoring Airway Smooth Muscle Cell Phenotype Via the ROS-AKT Pathway

Switching of airway smooth muscle (ASM) cell phenotype from differentiated-contractile to dedifferentiated-proliferative/synthetic state often occurs in asthmatic subjects with airway dysfunction. Evidence has been provided that chloroquine (an agonist of bitter taste receptors) presented benefits t...

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Detalles Bibliográficos
Autores principales: Ren, Yan, Zhong, Xiuhua, Wang, Hongyu, Chen, Zhongqi, Liu, Yanan, Zeng, Xiaoning, Ma, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198701/
https://www.ncbi.nlm.nih.gov/pubmed/35721212
http://dx.doi.org/10.3389/fphar.2022.916508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9198701/
https://www.ncbi.nlm.nih.gov/pubmed/35721212
http://dx.doi.org/10.3389/fphar.2022.916508

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